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A first in human study suggested that tirzepatide a dual GLP 1 and glucose dependent insulinotropic polypeptide (GIP) receptor agonist modulated abnormal activity in the brain's nucleus accumbens, thereby reducing food cravings and inducing The science of safety: adverse effects of #GLP 1 receptor agonists as glucose lowering and obesity medications As part of the JCI's Review Series on Clinical Innovation and Scientific Progress in GLP 1 Medicine, Michael Will Weight Loss Drugs Really Change Consumption Patterns? CZ app GLP 1 diabetes drugs like Ozempic may modestly reduce cancer risks Reuters Incretins role in metabolic homeostasis DMSO Dove Medical Press The Big Trial of a GLP 1 drug (Wegovy) to Reduce Major Cardiovascular Events
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Best in 7 days
Best in 7 days
Best in 7 days
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Best in 7 days
4.8 ★★★★★
Based on 2452 reviews
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Product Reviews
★★★★★ 3
Fit of shoe
Size: 9.5, Color: Brown
The shoes seems to run a bit narrow and tighter than the stated size. I plan to reorder the wide in the same size. They look great but I needed an easy to slip on shoe for my husband.
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Reviewed in the United States on May 10, 2026
★★★★★ 5
Great shoes
Size: 9.5, Color: Brown
Great comfort, true to fit size.
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Reviewed in the United States on June 7, 2026
★★★★★ 5
Great price great shoe
Size: 12, Color: Burgundy Polished Full Grain
Excellent shoe. Tried the Sebago penny loafer and the sizing was ridiculous. These J and M are sized perfectly. I’ve had them before and they wear like iron. Very comfortable right out of the box.
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Reviewed in the United States on May 23, 2026
★★★★★ 5
One of the best shoes
Size: 9.5, Color: Black Polished Full Grain
Outstanding. Fashionable, most comfortable and good construction. No sines of use after quite some time. Highly recommended.
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Reviewed in the United States on March 21, 2026
★★★★★ 4
Quality shoe but with a slight squeak.
Size: 10 Wide, Color: Burgundy Polished Full Grain
Nice shoes with the classic Penny Loafer design. Fit was better than another brand I tried. Only reason not 5 starts is disappointment due to a slight squeak at times when walking.
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Reviewed in the United States on August 11, 2025
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